Expression and clinical prognostic value of m6A RNA methylation modification in breast cancer.

ABSTRACT:

Background

N6-methyladenosine(m6A) methylation modification affects the tumorigenesis, progression, and metastasis of breast cancer (BC). However, the expression characteristics and prognostic value of m6A modification in BC are still unclear. We aimed to evaluate the relationship between m6A modification and clinicopathological characteristics, and to explore the underlying mechanisms.

Methods

Three public cohorts and our clinical cohort were included: 1091 BC samples and 113 normal samples from the TCGA database, 1985 BC samples from the METABRIC database, 1764 BC samples from the KM Plotter website, and 134 BC samples of our clinical cohort. We collected date from these cohorts and analyzed the genetic expression, gene-gene interactions, gene mutations, copy number variat

SUBMITTER: Zheng F 

PROVIDER: S-EPMC8082898 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature