Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury.

ABSTRACT: Long-term consequences of status epilepticus (SE) occur in a significant proportion of those who survive the acute episode. We developed an in vivo model of acute focal neocortical SE (FSE) to study long-term effects on local cortical structure and function and potential strategies to mitigate adverse consequences of SE. An acute 2 h episode of FSE was induced in anesthetized mice by epidural application of gabazine +4-aminopyridine over sensorimotor neocortex. Ten and 30 days later, the morphological and functional consequences of this single episode of FSE were studied using immunocytochemical and electrophysiological techniques. Results, focused on cortical layer V, showed astrogliosis, microgliosis, decreased neuronal density, and increased excitatory synapses, along with increased imm

SUBMITTER: Perez-Ramirez MB 

PROVIDER: S-EPMC8083016 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature