Neuroretinal Biomarkers for Schizophrenia Spectrum Disorders.

ABSTRACT:

Purpose

We evaluated the patient-control differences and predictive value of the retina as potential biomarkers for schizophrenia.

Methods

The institutional study included both eyes of 58 schizophrenia spectrum disorder (SSD) patients (age 37.2 ± 12.3 years) and 35 controls (age 41.1 ± 15.2 years). Retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer, outer retinal photoreceptor complex, and total macula thicknesses were measured by optical coherence tomography (OCT). Anterior segment parameters including central corneal thickness, anterior chamber depth, and axial length were measured to rule out confounds on the retinal measures.

Results

The peripapillary RNFL was overall significantly thinner in SSD relative to controls (F = 3.97, P = 0.049), most

SUBMITTER: Asanad S 

PROVIDER: S-EPMC8083086 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature