Coadministration With Carbidopa Enhances the Antimyopic Effects of Levodopa in Chickens.

ABSTRACT:

Purpose

Topical application of levodopa inhibits the development of form-deprivation myopia (FDM) and lens-induced myopia (LIM) in chicks. Here we examine whether coadministration with carbidopa enhances this protection and compare the effectiveness of topical versus systemic administration. We also investigate the degree to which topical and systemic administration of these compounds alters retinal dopamine release and examine whether this is the mechanism by which they inhibit experimental myopia.

Methods

Levodopa and levodopa:carbidopa (at a 4:1 ratio) were administered as twice-daily eye drops or once-daily intraperitoneal injections to chicks developing FDM or LIM over an ascending dose range. Axial length and refraction were measured following 4 days of treatment. Dopa

SUBMITTER: Thomson K 

PROVIDER: S-EPMC8083087 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature