Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden.

ABSTRACT:

Objective

To assess the risk of colorectal cancer (CRC) in first degree relatives (parents and full siblings) of patients with precursor lesions (polyps) for CRC.

Design

Case-control study.

Setting

Linkage to the multi-generation register and gastrointestinal ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) histopathology cohort in Sweden.

Participants

68 060 patients with CRC and 333 753 matched controls.

Main outcome measures

Multivariable adjusted odds ratios of CRC according to the number of first degree relatives with a colorectal polyp and the histology of polyps and age at diagnosis in first degree relatives. Subgroup analysis was also performed according to age at CRC diagnosis and evaluated the joint association of family

SUBMITTER: Song M 

PROVIDER: S-EPMC8083372 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature