Evidence of state-dependence in the effectiveness of responsive neurostimulation for seizure modulation.

ABSTRACT:

Background

An implanted device for brain-responsive neurostimulation (RNS® System) is approved as an effective treatment to reduce seizures in adults with medically-refractory focal epilepsy. Clinical trials of the RNS System demonstrate population-level reduction in average seizure frequency, but therapeutic response is highly variable.

Hypothesis

Recent evidence links seizures to cyclical fluctuations in underlying risk. We tested the hypothesis that effectiveness of responsive neurostimulation varies based on current state within cyclical risk fluctuations.

Methods

We analyzed retrospective data from 25 adults with medically-refractory focal epilepsy implanted with the RNS System. Chronic electrocorticography was used to record electrographic seizures, and hidden M

SUBMITTER: Chiang S 

PROVIDER: S-EPMC8083819 | biostudies-literature | 2021 Mar-Apr

REPOSITORIES: biostudies-literature