¹H, ¹³C, ¹⁵N and ³¹P chemical shift assignment for stem-loop 4 from the 5'-UTR of SARS-CoV-2.

ABSTRACT: The SARS-CoV-2 virus is the cause of the respiratory disease COVID-19. As of today, therapeutic interventions in severe COVID-19 cases are still not available as no effective therapeutics have been developed so far. Despite the ongoing development of a number of effective vaccines, therapeutics to fight the disease once it has been contracted will still be required. Promising targets for the development of antiviral agents against SARS-CoV-2 can be found in the viral RNA genome. The 5'- and 3'-genomic ends of the 30 kb SCoV-2 genome are highly conserved among Betacoronaviruses and contain structured RNA elements involved in the translation and replication of the viral genome. The 40 nucleotides (nt) long highly conserved stem-loop 4 (5_SL4) is located within the 5'-untranslated region (5'-

SUBMITTER: Vogele J 

PROVIDER: S-EPMC8083917 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature