Mining immune-related genes with prognostic value in the tumor microenvironment of breast invasive ductal carcinoma.

ABSTRACT:

Abstract

The tumor microenvironment (TME) plays an important role in the development of breast cancer. Due to limitations in experimental conditions, the molecular mechanism of TME in breast cancer has not yet been elucidated. With the development of bioinformatics, the study of TME has become convenient and reliable.Gene expression and clinical feature data were downloaded from The Cancer Genome Atlas database and the Molecular Taxonomy of Breast Cancer International Consortium database. Immune scores and stromal scores were calculated using the Estimation of Stromal and Immune Cells in Malignant Tumor Tissues Using Expression Data algorithm. The interaction of genes was examined with protein-protein interaction and co-expression analysis. The function of genes was analyzed by gen

SUBMITTER: He Q 

PROVIDER: S-EPMC8084029 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature