The association between white matter changes and development of malignant middle cerebral artery infarction: A case-control study.

ABSTRACT:

Abstract

Disrupted blood-brain barrier (BBB) in patients with ischemic stroke plays a critical role in malignant middle cerebral artery infarction (MMI) development.Cerebral white matter changes (WMC), particularly in the deep subcortical area or in severe one, may be also underlain by disrupted BBB. It is unclear whether the presence of WMC with potential premorbid disruption of BBB makes patients susceptible to MMI. Therefore, this study aimed to clarify any putative relationship between the MMI and WMC in terms of their severity and locations.In this case-control study, patients with infarction in the middle cerebral artery territory were retrospectively reviewed. Brain magnetic resonance images were analyzed according to Fazekas scale, and identified WMC were divided into periv

SUBMITTER: Wu MN 

PROVIDER: S-EPMC8084049 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature