Angiotensin converting enzyme inhibitors and risk of lung cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

We performed a meta-analysis to determine whether a consistent relationship exists between the use of angiotensin converting enzyme inhibitors (ACEIs) and the risk of lung cancer. Accordingly, we summarized and reviewed previously published quantitative studies.

Methods

Eligible studies with reference lists published before June 1st, 2019 were obtained from searching several databases. Random effects' models were used to summarize the overall estimate of the multivariate adjusted odds ratios (ORs) with 95% confidence intervals (CIs).

Results

Thirteen observational studies involving 458,686 ACEI users were included in the analysis, Overall, pooled risk ratios indicate that ACEIs use was not a risk factor for lung cancer (RR 0.982, 95% C.I. 0.873 - 1.104; P =

SUBMITTER: Batais M 

PROVIDER: S-EPMC8084080 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature