Purkinje Neurons with Loss of STIM1 Exhibit Age-Dependent Changes in Gene Expression and Synaptic Components.

ABSTRACT: The stromal interaction molecule 1 (STIM1) is an ER-Ca²⁺ sensor and an essential component of ER-Ca²⁺ store operated Ca²⁺ entry. Loss of STIM1 affects metabotropic glutamate receptor 1 (mGluR1)-mediated synaptic transmission, neuronal Ca²⁺ homeostasis, and intrinsic plasticity in Purkinje neurons (PNs). Long-term changes of intracellular Ca²⁺ signaling in PNs led to neurodegenerative conditions, as evident in individuals with mutations of the ER-Ca²⁺ channel, the inositol 1,4,5-triphosphate receptor. Here, we asked whether changes in such intrinsic neuronal properties, because of loss of STIM1, have an age-dependent impact on PNs. Consequently, we analyzed mRNA expression profiles and cerebellar morphology in PN-specific

SUBMITTER: Dhanya SK 

PROVIDER: S-EPMC8084323 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature