FGF10 and FGF13 genetic variation and tooth-size discrepancies.

ABSTRACT:

Objectives

To explore whether variations in odontogenesis-related genes are associated with tooth-size discrepancies.

Materials and methods

Measurements of the width of permanent teeth were obtained from dental casts of 62 orthodontic patients (age 15.65 ± 6.82 years; 29 males and 33 females). Participants were classified according to the anterior and overall Bolton ratios as without tooth-size discrepancy or with maxillary or mandibular tooth-size excess. Genomic DNA extracted from buccal cells was used, and 13 single nucleotide polymorphisms (SNPs) across nine genes were genotyped by polymerase chain reaction using TaqMan chemistry. χ2 or Fisher exact tests were applied to determine the overrepresentation of genotypes/alleles depending on the type of tooth-size discrepancy

SUBMITTER: Maranon-Vasquez GA 

PROVIDER: S-EPMC8084460 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature