Epidemiologic History and Genetic Diversity Origins of Chikungunya and Dengue Viruses, Paraguay.

ABSTRACT: Paraguay has been severely affected by emergent Zika and chikungunya viruses, and dengue virus is endemic. To learn more about the origins of genetic diversity and epidemiologic history of these viruses in Paraguay, we deployed portable sequencing technologies to strengthen genomic surveillance and determine the evolutionary and epidemic history of arthropod-borne viruses (arboviruses). Samples stored at the Paraguay National Central Laboratory were sequenced and subjected to phylogenetic analysis. Among 33 virus genomes generated, we identified 2 genotypes of chikungunya and 2 serotypes of dengue virus that circulated in Paraguay during 2014-2018; the main source of these virus lineages was estimated to be Brazil. The evolutionary history inferred by our analyses precisely matched the ava

SUBMITTER: Graf T 

PROVIDER: S-EPMC8084490 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature