Tissue-Resident Memory-Like CD8⁺ T Cells Exhibit Heterogeneous Characteristics in Tuberculous Pleural Effusion.

ABSTRACT: Tissue-resident memory T (T_RM) cells are well known to play critical roles in peripheral tissues during virus infection and tumor immunology. Our previous studies indicated that CD69⁺CD4⁺ and CD69⁺CD8⁺ T cells in tuberculous pleural effusion (TPE) were antigen-specific memory T cells. However, the phenotypical and functional characteristics of CD8⁺ T_RM cells in tuberculosis remain unknown. We found that CD103⁺CD8⁺ T cells were the predominant subset of CD103⁺ lymphocytes in TPE; both CD103 and CD69 expressed on memory CD8⁺ T cells from TPE were significantly increased compared with those from paired peripheral blood. Phenotypically, CD103⁺CD69⁺ and

SUBMITTER: Yu S 

PROVIDER: S-EPMC8084674 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature