Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text]C MRI.

ABSTRACT:

Background

Stereotactic radiosurgery (SRS) is used to manage intracranial metastases in a significant fraction of patients. Local progression after SRS can often only be detected with increased volume of enhancement on serial MRI scans which may lag true progression by weeks or months.

Methods

Patients with intracranial metastases (N = 11) were scanned using hyperpolarized [Formula: see text]C MRI prior to treatment with stereotactic radiosurgery (SRS). The status of each lesion was then recorded at six months post-treatment follow-up (or at the time of death).

Results

The positive predictive value of [Formula: see text]C-lactate signal, measured pre-treatment, for prediction of progression of intracranial metastases at six months post-treatment with SRS was 0.8 [Form

SUBMITTER: Lee CY 

PROVIDER: S-EPMC8084843 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature