Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders.

ABSTRACT: Mitochondria are the primary source of energy production in the brain thereby supporting most of its activity. However, mitochondria become inefficient and dysfunctional with age and to a greater extent in neurological disorders. Thus, mitochondria represent an emerging drug target for many age-associated neurological disorders. This review summarizes recent advances (covering from 2010 to May 2020) in the use of natural products from plant, animal, and microbial sources as potential neuroprotective agents to restore mitochondrial function. Natural products from diverse classes of chemical structures are discussed and organized according to their mechanism of action on mitochondria in terms of modulation of biogenesis, dynamics, bioenergetics, calcium homeostasis, and membrane potential, a

SUBMITTER: Liang Z 

PROVIDER: S-EPMC8084865 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature