Genetic and molecular subtype heterogeneity in newly diagnosed early- and advanced-stage endometrial cancer.

ABSTRACT:

Objective

To characterize and compare the molecular subtypes and profiles of prospectively-accrued newly-diagnosed early- and advanced-stage endometrial cancers (ECs).

Methods

EC patients consented to an IRB-approved protocol of massively parallel sequencing of 410-468 cancer-related genes; 175 ECs of 7 histologic types (n = 135 FIGO stages I/II, n = 40 FIGO stages III/IV) were included. Previously reported sequencing data from 99 additional advanced-stage ECs were retrieved for comparisons.

Results

Irrespective of histologic type, all 175 ECs could be stratified into the molecular subtypes, with 75 (43%) being of p53 wild-type, 49 (28%) MMR-deficient, 39 (22%) p53 abnormal and 12 (7%) of POLE molecular subtypes. Subtype distribution, mutational and copy number profil

SUBMITTER: Da Cruz Paula A 

PROVIDER: S-EPMC8085053 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature