Multiomic Predictors of Short-Term Weight Loss and Clinical Outcomes During a Behavioral-Based Weight Loss Intervention.

ABSTRACT:

Objective

Identifying predictors of weight loss and clinical outcomes may increase understanding of individual variability in weight loss response. We hypothesized that baseline multiomic features, including DNA methylation (DNAme), metabolomics, and gut microbiome, would be predictive of short-term changes in body weight and other clinical outcomes within a comprehensive weight loss intervention.

Methods

Healthy adults with overweight or obesity (n = 62, age 18-55 years, BMI 27-45 kg/m² , 75.8% female) participated in a 1-year behavioral weight loss intervention. To identify baseline omic predictors of changes in clinical outcomes at 3 and 6 months, whole-blood DNAme, plasma metabolites, and gut microbial genera were analyzed.

Results

A network of multiomi

SUBMITTER: Siebert JC 

PROVIDER: S-EPMC8085074 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature