Synthesis and Characterization of Cationic Dendrimer-PDMS Hybrids.

ABSTRACT: A modular strategy for the synthesis of dendron-linear polymer hybrids comprised of a flexible polydimethylsiloxane (PDMS) midblock with cationic 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) dendron end groups is developed. The invention of a scalable methodology to access quaternary ammonium carboxylate building blocks and their direct use in esterification chemistry enables rapid access to cationic bis-MPA dendrons. The convergent click coupling of highly charged dendrons to hydrophobic PDMS chain-ends gives a 12-membered family of hybrids that are comprised of different dendron generations (G1-3) and quaternary ammonium alkyl chain lengths (C₄ , C₈ , C₁₂ , C₁₆ ). This provides a library of materials with variable hydrophobicity, charge densi

SUBMITTER: Marks MA 

PROVIDER: S-EPMC8085078 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature