Frontline Science: The expression of integrin α_D β₂ (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis.

ABSTRACT: Neutrophil-macrophage interplay is a fine-tuning mechanism that regulates the innate immune response during infection and inflammation. Cell surface receptors play an essential role in neutrophil and macrophage functions. The same receptor can provide different outcomes within diverse leukocyte subsets in different inflammatory conditions. Understanding the variety of responses mediated by one receptor is critical for the development of anti-inflammatory treatments. In this study, we evaluated the role of a leukocyte adhesive receptor, integrin α_D β₂ , in the development of acute inflammation. α_D β₂ is mostly expressed on macrophages and contributes to the development of chronic inflammation. In contrast, we found that α_D -knockout dra

SUBMITTER: Bailey WP 

PROVIDER: S-EPMC8085079 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature