REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity.

ABSTRACT: Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking^1,2. The molecular mechanism that underlies this temporal pattern is unclear. Here we show that the nuclear receptors REV-ERB-α and REV-ERB-β (referred to here as 'REV-ERB') in the GABAergic (γ-aminobutyric acid-producing) neurons in the suprachiasmatic nucleus (SCN) (SCN^GABA neurons) control the diurnal rhythm of insulin-mediated suppression of hepatic glucose production in mice, without affecting diurnal eating or locomotor behaviours during regular light-dark cycles. REV-ERB regulates the rhythmic expression of genes that are involved in neurotransmission in the SCN, and modulates the oscillatory firing activity of SCN^GABA neurons. Chemogenetic stimulation of SCN^GABA ne

SUBMITTER: Ding G 

PROVIDER: S-EPMC8085086 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature