Metabolomic profiling for second primary lung cancer: A pilot case-control study.

ABSTRACT:

Objectives

Lung cancer survivors have a high risk of developing a second primary lung cancer (SPLC). While national screening guidelines have been established for initial primary lung cancer (IPLC), no consensus guidelines exist for SPLC. Furthermore, the factors that contribute to SPLC risk have not been established. This study examines the potential for using serum metabolomics to identify metabolite biomarkers that differ between SPLC cases and IPLC controls.

Material and methods

In this pilot case-control study, we applied an untargeted metabolomics approach based on ultrahigh performance liquid chromatography-tandem mass spectroscopy (UPLC-MS/MS) to serum samples of 82 SPLC cases and 82 frequency matched IPLC controls enrolled in the Boston Lung Cancer Study. Random for

SUBMITTER: Aredo JV 

PROVIDER: S-EPMC8085101 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature