Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage.

ABSTRACT:

Background and objectives

IL-6 (interleukin 6) is a proinflammatory cytokine and an established biomarker in acute brain injury. We sought to determine whether admission IL-6 levels are associated with severity and functional outcome after spontaneous intracerebral hemorrhage (ICH).

Methods

We performed an exploratory analysis of the recombinant activated FAST trial (Factor VII for Acute ICH). Patients with admission serum IL-6 levels were included. Regression analyses were used to assess the associations between IL-6 and 90-day modified Rankin Scale. In secondary analyses, we used linear regression to evaluate the association between IL-6 and baseline ICH and perihematomal edema volumes.

Results

Of 841 enrolled patients, we included 552 (66%) with available admission

SUBMITTER: Leasure AC 

PROVIDER: S-EPMC8085132 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature