Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain.

ABSTRACT:

Background and purpose

Brain tissue-resident microglia and monocyte-derived macrophages (MDMs) are innate immune cells that contribute to the inflammatory response, phagocytosis of debris, and tissue repair after injury. We have previously reported that both microglia and MDMs transition from proinflammatory to reparative phenotypes over days after an intracerebral hemorrhage (ICH). However, their individual functional properties in the brain remain largely unknown. Here we characterized the differences between microglia and MDMs and further elucidate their distinct activation states and functional contributions to the pathophysiology and recovery after ICH.

Methods

Autologous blood injection was used to model ICH in mice. Longitudinal transcriptomic analyses on isolated mic

SUBMITTER: Chang CF 

PROVIDER: S-EPMC8085165 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature