Multiple dimensions of stress vs. genetic effects on depression.

ABSTRACT: Many psychiatric disorders including depression involve complex interactions of genetics and environmental stressors. Environmental influence is challenging to measure objectively and account for in genetic studies because the necessary large population samples in these studies involve individuals with varying cultures and life experiences, clouding genetic findings. In a unique population with relative sociocultural homogeneity and a narrower range of types of stress experiences, we quantitatively assessed multiple stress dimensions and measured their potential influence in biasing the heritability estimate of depression. We quantified depressive symptoms, major lifetime stressors, current perceived stress, and a culturally specific community stress measure in individuals with depression-

SUBMITTER: Kvarta MD 

PROVIDER: S-EPMC8085217 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature