Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep.

ABSTRACT: Gastrointestinal nematode (GIN) infections have negative impacts on animal health, welfare and production. Information from molecular studies can highlight the underlying genetic mechanisms that enhance host resistance to GIN. However, such information often lacks for traditionally managed indigenous livestock. Here, we analysed 600 K single nucleotide polymorphism genotypes of GIN infected and non-infected traditionally managed autochthonous Tunisian sheep grazing communal natural pastures. Population structure analysis did not find genetic differentiation that is consistent with infection status. However, by contrasting the infected versus non-infected cohorts using ROH, LR-GWAS, F_ST and XP-EHH, we identified 35 candidate regions that overlapped between at least two methods. N

SUBMITTER: Ahbara AM 

PROVIDER: S-EPMC8085236 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature