Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer.

ABSTRACT: Upregulated MYCN gene expression is restricted to specialized cell populations such as EpCAM⁺ cancer stem cells in liver cancer, regardless of DNA amplification and mutation. Here, we reviewed the role of MYCN gene expression in liver homeostasis, regeneration, and tumorigenesis, and discussed the potential non-genomic mechanisms involved in controlling MYCN gene expression in liver cancer, with a focus on inflammation-mediated signal transduction and microRNA-associated post-transcriptional regulation. We concluded that dynamic MYCN gene expression is an integrated consequence of multiple signals in the tumor microenvironment, including tumor growth-promoting signals, lipid desaturation-mediated endoplasmic reticulum stress adaptation signals, and tu

SUBMITTER: Qin XY 

PROVIDER: S-EPMC8085327 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature