Inhibiting Pyridoxal Kinase of Entamoeba histolytica Is Lethal for This Pathogen.

ABSTRACT: Pyridoxal 5'-phosphate (PLP) functions as a cofactor for hundreds of different enzymes that are crucial to the survival of microorganisms. PLP-dependent enzymes have been extensively characterized and proposed as drug targets in Entamoeba histolytica. This pathogen is unable to synthesize vitamin B_6via de-novo pathway and relies on the uptake of vitamin B₆ vitamers from the host which are then phosphorylated by the enzyme pyridoxal kinase to produce PLP, the active form of vitamin B₆. Previous studies from our lab shows that EhPLK is essential for the survival and growth of this protozoan parasite and its active site differs significantly with respect to its human homologue making it a potential drug target. In-silico

SUBMITTER: Devi S 

PROVIDER: S-EPMC8085340 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature