A Novel Immune-Related Prognostic Biomarker and Target Associated With Malignant Progression of Glioma.

ABSTRACT:

Background

Glioma is one of the most common malignancies in the central nervous system and has limited effective therapeutic options. Therefore, we sought to identify a suitable target for immunotherapy.

Materials and methods

We screened prognostic genes for glioma in the CGGA database and GSE43378 dataset using survival analysis, receiver operating characteristic (ROC) curves, independent prognostic analysis, and clinical correlation analysis. The results were intersected with immune genes from the ImmPort database through Venn diagrams to obtain likely target genes. The target genes were validated as prognostically relevant immune genes for glioma using survival, ROC curve, independent prognostic, and clinical correlation analyses in samples from the CGGA database and GSE4

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8085360 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature