Role of Circulating T Follicular Helper Cells and Stem-Like Memory CD4⁺ T Cells in the Pathogenesis of HIV-2 Infection and Disease Progression.

ABSTRACT: CD4⁺ T cells are critical players in the host adaptive immune response. Emerging evidence suggests that certain CD4⁺ T cell subsets contribute significantly to the production of neutralizing antibodies and help in the control of virus replication. Circulating T follicular helper cells (Tfh) constitute a key T cell subset that triggers the adaptive immune response and stimulates the production of neutralizing antibodies (NAbs). T cells having stem cell-like property, called stem-like memory T cells (Tscm), constitute another important subset of T cells that play a critical role in slowing the rate of disease progression through the differentiation and expansion of different types of memory cell subsets. However, the role of these immune cell subsets in T cell homeostas

SUBMITTER: Ponnan SM 

PROVIDER: S-EPMC8085399 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature