Designing Multi-Antigen Vaccines Against Acinetobacter baumannii Using Systemic Approaches.

ABSTRACT: Vaccines and monoclonal antibodies are promising approaches for preventing and treating infections caused by multidrug resistant Acinetobacter baumannii. However, only partial protection has been achieved with many previously tested protein antigens, which suggests that vaccines incorporating multiple antigens may be necessary in order to obtain high levels of protection. Several aspects that use the wealth of omic data available for A. baumannii have not been fully exploited for antigen identification. In this study, the use of fractionated proteomic and computational data from ~4,200 genomes increased the number of proteins potentially accessible to the humoral response to 8,824 non-redundant proteins in the A. baumannii panproteome. Among them, 59% carried predicted

SUBMITTER: McConnell MJ 

PROVIDER: S-EPMC8085427 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature