Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease.

ABSTRACT:

Background

Glucagon-like peptide-1 receptor (GLP-1R) agonists are approved to treat type 2 diabetes and obesity. They elicit robust improvements in glycemic control and weight loss, combined with cardioprotection in individuals at risk of or with pre-existing cardiovascular disease. These attributes make GLP-1 a preferred partner for next-generation therapies exhibiting improved efficacy yet retaining safety to treat diabetes, obesity, non-alcoholic steatohepatitis, and related cardiometabolic disorders. The available clinical data demonstrate that the best GLP-1R agonists are not yet competitive with bariatric surgery, emphasizing the need to further improve the efficacy of current medical therapy.

Scope of review

In this article, we discuss data highlighting the physiologi

SUBMITTER: Baggio LL 

PROVIDER: S-EPMC8085566 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature