In vitro effects-based method and water quality screening model for use in pre- and post-distribution treated waters.

ABSTRACT: Recent urban public water supply contamination events emphasize the importance of screening treated drinking water quality after distribution. In vitro bioassays, when run concurrently with analytical chemistry methods, are effective tools to evaluating the efficacy of water treatment processes and water quality. We tested 49 water samples representing the Chicago Department of Water Management service areas for estrogen, (anti)androgen, glucocorticoid receptor-activating contaminants and cytotoxicity. We present a tiered screening approach suitable to samples with anticipated low-level activity and initially tested all extracts for statistically identifiable endocrine activity; performing a secondary dilution-response analysis to determine sample EC₅₀ and biological equivalency

SUBMITTER: Medlock Kakaley E 

PROVIDER: S-EPMC8085790 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature