Lycorine hydrochloride inhibits melanoma cell proliferation, migration and invasion via down-regulating p21^Cip1/WAF1.

ABSTRACT: Lycorine hydrochloride (LH) is an active ingredient sourced from the medicinal herb Lycoris radiata. Previous studies have suggested that LH exerts tumor suppression activity in several human cancers. However, the anti-cancer effect of LH in melanoma and the potential molecular mechanisms still need to be further studied. p21^Cip1/WAF1, unlike its traditional cyclin-dependent kinase (CDK) inhibitor role, is believed to act as an oncogene under certain cellular conditions. In this research, an increased expression of p21^Cip1/WAF1 was found in human melanoma tissues and positively related to the tumor invasion depth. High level of p21^Cip1/WAF1 was found to correlate with bad outcomes of melanoma patients by Kaplan-Meier survival analysis. Functional exp

SUBMITTER: Shi S 

PROVIDER: S-EPMC8085853 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature