Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3.

ABSTRACT: Platelet activation and pulmonary recruitment occur in patients with asthma and in animal models of allergic asthma, in which leukocyte infiltration, airway remodeling, and hyperresponsiveness are suppressed by experimental platelet depletion. These observations suggest the importance of platelets to various characteristics of allergic disease, but the mechanisms of platelet migration and location are not understood. The aim of this study was to assess the mechanism of platelet recruitment to extravascular compartments of lungs from patients with asthma and after allergen challenge in mice sensitized to house dust mite (HDM) extract (contains the DerP1 [Dermatophagoides pteronyssinus extract peptidase 1] allergen); in addition, we assessed the role of chemokines in this process. Lun

SUBMITTER: Shah SA 

PROVIDER: S-EPMC8086046 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature