Galactosaminogalactan activates the inflammasome to provide host protection.

ABSTRACT: Inflammasomes are important sentinels of innate immune defence that are activated in response to diverse stimuli, including pathogen-associated molecular patterns (PAMPs)¹. Activation of the inflammasome provides host defence against aspergillosis^2,3, which is a major health concern for patients who are immunocompromised. However, the Aspergillus fumigatus PAMPs that are responsible for inflammasome activation are not known. Here we show that the polysaccharide galactosaminogalactan (GAG) of A. fumigatus is a PAMP that activates the NLRP3 inflammasome. The binding of GAG to ribosomal proteins inhibited cellular translation machinery, and thus activated the NLRP3 inflammasome. The galactosamine moiety bound to ribosomal proteins and blocked cellular translation, which

SUBMITTER: Briard B 

PROVIDER: S-EPMC8086055 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature