Application of a framework to guide genetic testing communication across clinical indications.

ABSTRACT:

Background

Genetic information is increasingly relevant across healthcare. Traditional genetic counseling (GC) may limit access to genetic information and may be more information and support than some individuals need. We report on the application and clinical implications of a framework to consistently integrate genetics expertise where it is most useful to patients.

Methods

The Clinical Genome Resource's (ClinGen) Consent and Disclosure Recommendations (CADRe) workgroup designed rubrics to guide pre- and post-genetic test communication. Using a standard set of testing indications, pre- and post-test rubrics were applied to 40 genetic conditions or testing modalities with diverse features, including variability in levels of penetrance, clinical actionability, and evidence s

SUBMITTER: Hallquist MLG 

PROVIDER: S-EPMC8086064 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature