Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer.

ABSTRACT:

Background

Abnormal DNA methylation is observed as an early event in breast carcinogenesis. However, how such alterations arise is still poorly understood. microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and play key roles in various biological processes. Here, we integrate miRNA expression and DNA methylation at CpGs to study how miRNAs may affect the breast cancer methylome and how DNA methylation may regulate miRNA expression.

Methods

miRNA expression and DNA methylation data from two breast cancer cohorts, Oslo2 (n = 297) and The Cancer Genome Atlas (n = 439), were integrated through a correlation approach that we term miRNA-methylation Quantitative Trait Loci (mimQTL) analysis. Hierarchical clustering was used to identify clusters of miRNAs

SUBMITTER: Aure MR 

PROVIDER: S-EPMC8086068 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature