Genetic impacts on DNA methylation: research findings and future perspectives.
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ABSTRACT:
SUBMITTER: Villicana S
PROVIDER: S-EPMC8086086 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Genetic impacts on DNA methylation: research findings and future perspectives.
Villicaña Sergio S Bell Jordana T JT
Genome biology 20210430 1
Multiple recent studies highlight that genetic variants can have strong impacts on a significant proportion of the human DNA methylome. Methylation quantitative trait loci, or meQTLs, allow for the exploration of biological mechanisms that underlie complex human phenotypes, with potential insights for human disease onset and progression. In this review, we summarize recent milestones in characterizing the human genetic basis of DNA methylation variation over the last decade, including heritabili ...[more]
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