Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function.

ABSTRACT:

Objective

Neuroimmune interactions between the sympathetic nervous system (SNS) and macrophages are required for the homeostasis of multiple tissues, including the adipose tissue. It has been proposed that the SNS maintains adipose tissue macrophages (ATMs) in an anti-inflammatory state via direct norepinephrine (NE) signaling to macrophages. This study aimed to investigate the physiological importance of this paradigm by utilizing a mouse model in which the adrenergic signaling from the SNS to macrophages, but not to other adipose tissue cells, was disrupted.

Methods

We generated a macrophage-specific B2AR knockout mouse (Adrb2^ΔLyz2) by crossing Adrb2^fl/fl and Lyz2^Cre/+ mice. We have previously shown that macrophages isolated from Adrb2

SUBMITTER: Petkevicius K 

PROVIDER: S-EPMC8086137 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature