The association between XRCC3 rs1799794 polymorphism and cancer risk: a meta-analysis of 34 case-control studies.

ABSTRACT:

Background

Studies on the XRCC3 rs1799794 polymorphism show that this polymorphism is involved in a variety of cancers, but its specific relationships or effects are not consistent. The purpose of this meta-analysis was to investigate the association between rs1799794 polymorphism and susceptibility to cancer.

Methods

PubMed, Embase, the Cochrane Library, Web of Science, and Scopus were searched for eligible studies through June 11, 2019. All analyses were performed with Stata 14.0. Subgroup analyses were performed by cancer type, ethnicity, source of control, and detection method. A total of 37 studies with 23,537 cases and 30,649 controls were included in this meta-analysis.

Results

XRCC3 rs1799794 increased cancer risk in the dominant model and heterozygous model (

SUBMITTER: Liu W 

PROVIDER: S-EPMC8086287 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature