Identification of a ferroptosis-related gene signature predictive model in colon cancer.

ABSTRACT:

Background

The prognosis of colon cancer (CC) is challenging to predict due to its highly heterogeneous nature. Ferroptosis, an iron-dependent form of cell death, has roles in various cancers; however, the correlation between ferroptosis-related genes (FRGs) and prognosis in CC remains unclear.

Methods

The expression profiles of FRGs and relevant clinical information were retrieved from the Cancer Genome Atlas (TCGA) database. Cox regression analysis and the least absolute shrinkage and selection operator (LASSO) regression model were performed to build a prognostic model in TCGA cohort.

Results

Ten FRGs, five of which had mutation rates ≥ 3%, were found to be related to the overall survival (OS) of patients with CC. Patients were divided into high- and low-risk group

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8086290 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature