Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjogren syndrome: a case report and literature review.

ABSTRACT:

Background

Acquired Gitelman syndrome is a very rare disorder reported in association with autoimmune disorders, mostly Sjögren syndrome. It is characterized by the presence of hypokalaemic metabolic alkalosis, hypocalciuria, hypomagnesaemia and hyper-reninaemia, in the absence of typical genetic mutations associated with inherited Gitelman syndrome.

Case presentation

A 20 year old woman who was previously diagnosed with primary Sjögren syndrome and autoimmune thyroiditis presented with two week history of lower limb weakness and salt craving. Examination revealed upper limb and lower limb muscle weakness with muscle power of 3/5 on MRC scale and diminished deep tendon reflexes. On evaluation, she had hypokalaemia with high trans-tubular potassium gradient, metabolic alkalos

SUBMITTER: Ranaweerage R 

PROVIDER: S-EPMC8086307 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature