Triaging HPV-positive, cytology-negative cervical cancer screening results with extended HPV genotyping and p16^INK4a immunostaining in China.

ABSTRACT:

Background

Self-sampling for human papillomavirus (HPV) testing is a feasible option to improve the cervical screening coverage. However, an ideal triage method for HPV-positive self-samples does not yet exist. The aim of this study was to explore the utility of HPV genotyping and p16^INK4a immunostaining (p16) in triaging HPV-positive self-samples, focusing on HPV-positive, cytology-negative (HPCN) women.

Methods

A total of 73,699 women were screened in a cervical screening project in China via SeqHPV assay on self-samples. HPV-positive women were called-back and collected cervical sample for p16 immunostaining and liquid-based cytology, those who met any result of HPV16/18+ or visual inspection with acetic acid (VIA) + or p16+ were referred for colposcopy, and HP

SUBMITTER: Song F 

PROVIDER: S-EPMC8086315 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature