Variants That Differentiate Wolf and Dog Populations Are Enriched in Regulatory Elements.

ABSTRACT: Research on the genetics of domestication most often focuses on the protein-coding exons. However, exons cover only a minor part (1-2%) of the canine genome, whereas functional mutations may be located also in regions beyond the exome, in regulatory regions. Therefore, a large proportion of phenotypical differences between dogs and wolves may remain genetically unexplained. In this study, we identified variants that have high allelic frequency differences (i.e., highly differentiated variants) between wolves and dogs across the canine genome and investigated the potential functionality. We found that the enrichment of highly differentiated variants was substantially higher in promoters than in exons and that such variants were enriched also in enhancers. Several enriched pathways were iden

SUBMITTER: Sahlen P 

PROVIDER: S-EPMC8086526 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature