Response to Ventilator Adjustments for Predicting Acute Respiratory Distress Syndrome Mortality. Driving Pressure versus Oxygenation.

ABSTRACT: Rationale: Clinicians commonly use short-term physiologic markers to assess the benefit of ventilator adjustments. Improved arterial oxygen tension/pressure (Pa_O2)/fraction of inspired oxygen (Fi_O2) after ventilator adjustment in acute respiratory distress syndrome is associated with lower mortality. However, as driving pressure (ΔP) reflects lung stress and strain, changes in ΔP may more accurately reflect benefits or harms of ventilator adjustments compared with changes in oxygenation.Objectives: We aimed to compare the association between mortality and the changes in Pa_O2/Fi_O2 and ΔP following protocolized ventilator changes.Methods: We assessed associations between mortality and

SUBMITTER: Yehya N 

PROVIDER: S-EPMC8086544 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature