Rationale for ozone-therapy as an adjuvant therapy in COVID-19: a narrative review.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is the respiratory disease caused by the novel severe acute respiratory syndrome-coronavirus-2 and is characterized by clinical manifestations ranging from mild, flu-like symptoms to severe respiratory insufficiency and multi-organ failure. Patients with more severe symptoms may require intensive care treatments and face a high mortality risk. Also, thrombotic complications such as pulmonary embolisms and disseminated intravascular coagulation are frequent in these patients. Indeed, COVID-19 is characterized by an abnormal inflammatory response resembling a cytokine storm, which is associated to endothelial dysfunction and microvascular complications. To date, no specific treatments are available for COVID-19 and its life-threatening complication. Immuno

SUBMITTER: Ranaldi GT 

PROVIDER: S-EPMC8086623 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature