Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.

ABSTRACT:

Aims

Misclassification of diabetes is common due to an overlap in the clinical features of type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and biomarker information have recently been developed that can aid classification, but they have not been validated using pancreatic pathology. We evaluated a clinical diagnostic model against histologically defined type 1 diabetes.

Methods

We classified cases from the Network for Pancreatic Organ donors with Diabetes (nPOD) biobank as type 1 (n = 111) or non-type 1 (n = 42) diabetes using histopathology. Type 1 diabetes was defined by lobular loss of insulin-containing islets along with multiple insulin-deficient islets. We assessed the discriminative performance of previously described type 1 diabetes diag

SUBMITTER: Carr ALJ 

PROVIDER: S-EPMC8086995 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature