The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans.

ABSTRACT: Intestinal epithelial cells are subject to attack by a diverse array of microbes, including intracellular as well as extracellular pathogens. While defense in epithelial cells can be triggered by pattern recognition receptor-mediated detection of microbe-associated molecular patterns, there is much to be learned about how they sense infection via perturbations of host physiology, which often occur during infection. A recently described host defense response in the nematode C. elegans called the Intracellular Pathogen Response (IPR) can be triggered by infection with diverse natural intracellular pathogens, as well as by perturbations to protein homeostasis. From a forward genetic screen, we identified the C. elegans ortholog of purine nucleoside phosphorylase pnp-1 as a negative regulator

SUBMITTER: Tecle E 

PROVIDER: S-EPMC8087013 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature