The impact of race and ethnicity on lipoprotein(a) levels and cardiovascular risk.

ABSTRACT:

Purpose of review

Lipoprotein(a) [Lp(a)] is a plasma circulating apoB100 (apoB) containing lipoprotein. It has a unique glycoprotein bound to the apoB100, apolipoprotein(a) [apo(a)]. The majority of the population expresses two apo(a) isoforms, when bound to apoB100 they create two circulating Lp(a) particles. Lp(a) levels are genetically determined and epidemiological studies have established elevated levels of Lp(a) to be a causal risk factor of cardiovascular disease (CVD). Lp(a) levels differ across racial groups and Blacks of Sub-Saharan decent have higher levels when compared to white. In comparison to white populations, studies in minorities are less represented in the published literature. Additionally, there is a lack of standardization in the commercial assays used to mea

SUBMITTER: Reyes-Soffer G 

PROVIDER: S-EPMC8087179 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature